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Research area: Scientific and research activities is focused on supramolecular chemistry and synthesis and properties of nanomaterial in chemistry and biotechnologies.Particular interest is also devoted to the mechanisms and synthetic applications of radical reactions and organofluorine compounds of pharmacological and agrochemical interest.Experimental and in silico procedures are used to predict molecular properties, chemical reactivity, quantitative structure-activity relationships and applied in several chemical and biomedical problems.

Research units

Chemoinformatica e Modellistica Molecolare (Coordinator Prof. Gabriele Cruciani)

The research projects cover the development and application of new experimental, in silico and cheminformatic algorithms to derive appropriate strategies for solving real problems in chemistry, namely in the field of quantitative structure-activity relationships (QSAR) applied in drug discovery and optimization, human metabolism, human toxicity, food and environmental chemistry.

Nanomaterials in biotechnology: synthesis and applications (Coordinator Prof. Antonio Cipiciani)

The research work focuses on the synthesis and characterization of a wide variety of hydrotalcite-like compounds having nanostructured dimensions and/or luminescent properties. The obtained nanomaterials are used in the study of: Interaction mechanisms between protein and nanostructured materials at liquid-solid interfaces. Catalytic behaviour and structural properties of enzymes adsorbed onto nanosized surfaces. Intercalation and release of pharmacologically active molecules from layered materials.

Synthesis of organofluorine compounds of pharmacological and agrochemical interest (Coordinator Prof. Renzo Ruzziconi)

Synthesis of novel quinolinophane-based chiral ligands and organocatalysts to be applied in enantioselective processes. Synthesis of chiral fluoroorganic compounds of biological interest. Development of new and quite general approach to regioselectively substituted 3-methyleneindolines as valuable building blocks to approach a variety of regio- and stereoselectively fluoro-, trifluoromethyl- and trifluoromethoxy-substituted indoles of pharmaceutical and agrochemical interest Assignment of the absolute configuration to chiral fluoroorganic compound based on the analysis of their ECD and VCD spectra.

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